Transcription Factors Dial 14-3-3 for Nuclear Shuttle
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چکیده
منابع مشابه
Transcription factors dial 14-3-3 for nuclear shuttle.
14-3-3 proteins are a highly conserved family of phosphoserine binding proteins found in all eukaryotes. The name “14-3-3” comes from the specific ion exchange chromatography elution profiles and starch gel electrophoresis migration patterns of a group of proteins originally isolated from mammalian brain tissue. 14-3-3 proteins play key roles in many diverse physiological processes that involve...
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14-3-3 proteins form a family of highly conserved eukaryotic proteins involved in a wide variety of cellular processes, including signalling, apoptosis, cell-cycle control and transcriptional regulation. More than 150 binding partners have been found for these proteins. The yeast Saccharomyces cerevisiae has two genes encoding 14-3-3 proteins, BMH1 and BMH2. A bmh1 bmh2 double mutant is unviabl...
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So what’s so interesting about them? In 1996 14-3-3 was found to bind to a variety of oncoproteins including Raf-1, polyoma middle T, and Bcr-Abl. Since then the 14-3-3 proteins have been shown to bind to a wide variety of proteins involved in signal transduction, cell cycle and apoptosis. These proteins include Cdc25, NFAT, Bad, Cbl, A20, PI 3-kinase, IRS-1, MEKK, p130Cas, glucocorticoid recep...
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ژورنال
عنوان ژورنال: The Plant Cell
سال: 2001
ISSN: 1040-4651,1532-298X
DOI: 10.1105/tpc.131110